Protein Molecular Weight Markers
ABclonal Technology CRM1/XPO1 Rabbit pAb
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
ABclonal Technology PDP1 Rabbit pAb
Pyruvate dehydrogenase (E1) is part of the pyruvate dehydrogenase complex (E1, E2, E3), with E1 activity regulated by phosphorylation and dephosphorylation. Pyruvate dehydrogenase kinases inactivate E1 by phosphorylating serine residues, while pyruvate dehydrogenase phosphatases activate E1 by dephosphorylation. The phosphatase is a heterodimer with catalytic and regulatory subunits. The catalytic subunit encoded by this gene is predominantly expressed in skeletal muscle and belongs to the protein phosphatase 2C (PP2C) superfamily. Located in the mitochondrial matrix, this enzyme, along with pyruvate dehydrogenase and kinases, regulates pyruvate metabolism. Mutations in this gene lead to pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced isoforms have been identified.
ABclonal Technology KLHL9 Rabbit pAb
This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes.
ABclonal Technology MYOCD Rabbit pAb
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology CAST Rabbit pAb
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Medchemexpress LLC 3-Color Prestained Protein Marker (10-190 kDa)
MCE 3-Color Prestained Protein Marker has 8 blue-stained bands and 2 reference bands (one green and one orange band at 23 kDa and 65 kDa respectively). This Protein Marker is designed for monitoring protein separation during SDS-PAGE, confirming Western blot transfer efficiency on membranes (PVDF or nitrocellulose membrane) and for approximating the size of target proteins on the gel or blot.MCE 3-Color Prestained Protein Marker is supplied in gel loading buffer and is ready to use, with no heating, diluting or additional reducing agent necessary.
ABclonal Technology TIMP2 Rabbit pAb
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
ABclonal Technology FREM2 Rabbit pAb
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome.
ABclonal Technology Bid Rabbit pAb
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8), CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found.
ABclonal Technology NOL6 Rabbit pAb
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.
ABclonal Technology AMPKα2 Rabbit pAb
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
ABclonal Technology USP37 Rabbit pAb
Enables cysteine-type endopeptidase activity, protein kinase binding activity, and thiol-dependent deubiquitinase. Involved in G1/S transition of mitotic cell cycle, protein deubiquitination, and regulation of DNA replication. Located in nucleus.
Cell Signaling Technology Biotinylated Protein Ladder Detection Pack 650 µl
Biotinylated Protein Ladder Detection Pack 650 µl
ABclonal Technology eIF2α Rabbit pAb
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2, MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).